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Centre Cambridge


List of publications from CBR-supported research studies acknowledging the Cambridge BioResource

Further studies and publications for the NIHR BioResource can be found on the NIHR BioResource website: 


Dami A. Collier, Isabella A.T.M. Ferreira, Rawlings Datir, Bo Meng, Laura Bergamaschi, The CITIID-NIHR BioResource COVID-19 Collaboration3 , Anne Elmer, Nathalie Kingston, Barbara Graves, Kenneth GC Smith, John R. Bradley, Paul A. Lyons1, Lourdes Ceron-Gutierrez L, Gabriela Barcenas-Morales, Rainer Doffinger, Mark Wills, Ravindra K. Gupta. Age-related heterogeneity in Neutralising antibody responses to SARS-CoV-2 following BNT162b2 vaccination. Age-related heterogeneity in Neutralising antibody responses to SARS-CoV-2 following BNT162b2 vaccination (


Foad J Rouhani, Xueqing Zou, Petr Danecek, Tauanne Dias Amarante, Gene Koh, Qianxin Wu, Yasin Memari, Richard Durbin, Inigo Martincorena, Andrew R Bassett, Daniel Gaffney, Serena Nik-Zainal. Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells. Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells (



Li Chen, Ruirui YangTony KwanChao TangStephen WattYiming ZhangGuillaume BourqueBing GeKate DownesMattia FrontiniWillem H. OuwehandJing-wen LinNicole SoranzoTomi Pastinen & Lu Chen. Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells. Published 9th November 2020 -

John Bradley, Ken Smith, Willem Ouwehand, Luke Meredith, Stuart Bloor, Ane Ogbe, Anna Yakovleva, Tiffeney Man, Laura Bergamaschi, Lorinda Turner, Frederica Mescia, Lourdes Ceron-Gutierrez, Jimstan Periselneris, Sorena Kiani-Alikhan, Devan Vaghela, Sara E. Lear, Estee Torok, William L. Hamilton, Paul Lyons, Rainer Donger , Ian Goodfellow ,Paul Lehner ,  Nick Matheson , James Thaventhiran. Successful treatment of COVID-19 with remdesivir in the absence of humoral immunity. Published September 2020 -

Lucy Rivett, Sushmita Sridhar, Dominic Sparkes, Matthew Routledge, Nick K. Jones, Sally Forrest, Jamie Young, Joana Pereira-Dias, William L. Hamilton, Mark Ferris, M. Estee Torok, Luke Meredith, The CITIID-NIHR COVID-19 BioResource Collaboration, Martin Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, Prof. Richard J. Samworth, Prof. John R. Bradley, Prof. Gordon Dougan, Prof. Kenneth G.C. Smith, Prof. Paul J. Lehner, Nicholas J. Matheson, Giles Wright, BA7 , Prof. Ian Goodfellow, Prof. Stephen Baker, Michael P. Weekes. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in 2 COVID-19 transmission, Published on May 16, 2020.

Gaëlle Marenne, Audrey E.Hendricks, Aliki Perdikari, Rebecca Bounds, Felicity Payne, Julia M.Keogh, Christopher J.Lelliott, Elana Henning, Saad Pathan, Sofie Ashford, Elena G.Bochukova, Vanisha Mistry, Allan Daly, Caroline Hayward, INTERVAL, UK10K Consortium Nicholas, J.Wareham, Stephen O’Rahilly, Claudia Langenberg, inês Barroso. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Volume 31, Issue 6, 2 June 2020, Pages 1107-1119.e12.


Richard, A., Peters, J., Savinykh, N., Lee, J., Hawley, E., Meylan, F., Siegel, R., Lyons, P., Smith, K. Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease. PLOS Genetics 2018, volume 14, issue 9, Published on September 10, 2018.

Williams-Gray, C., Wijeyekoon, R., Scott, K., Hayat, S., Barker, R., Jones, J. Abnormalities of age-related T cell senescence in Parkinson's disease. Journal of Neuroinflammation 2018;15(1):166.

Wang, J., Ferreira, R., Lu, W., Farrow, S., Downes, K., Jermutus, L., Minter, R., R Al-Lamki,R., Pober, J., & Bradley, J. TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway. Nature, Scientific Reports, volume 8, Article number: 12079 (2018)

Smets, I., Fiddes, B., Garcia-Perez, J.E., He, D., Mallants, K., Liao, W., Dooley, J., Wang, G., Humblet-Baron, S., Dubois, B., Compston, A., Jones, J., Coles, A., Liston, A., Ban, M., Goris, A. and Sawcer, S. Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells. BRAIN 2018. DOI: 10.1093/brain/awx372.

Alasoo, K., Rodrigues, J., Mukhopadhyay, S., Knights, A., Mann, A., Kundu, K., HIPSCI Consortium, Hale, C., Dougan, G., and Gaffney, D. Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response. Nature Geneticsvolume 50, pages424–431 (2018)


Schormair, B., Zhao, C., Bell, S., Tilch, E., Salminen, A.V., Pütz, B., Dauvilliers, Y., Stefani, A., Högl, B., Poewe, W., Kemlink, D., Sonka, K., Bachmann, C.G., Paulus, W., Trenkwalder, C., Oertel, W.H.o, Hornyak, M., Teder-Laving, M., Metspalu, A., Hadjigeorgiou, G.M., Polo, O., Fietze, I., Ross, O.A., Wszolek, Z., Butterworth, A.S., Soranzo, N., Ouwehand, W.H., Roberts, D.J., Danesh, J., Allen, R.P., Earley, C.J., Ondo, W.G., Xiong, L., Montplaisir, J., Gan-Or, Z., Perola, M., Vodicka, P., Dina, C., Franke, A., Tittmann, L., Stewart, A.F.R., Shah, S.H., Gieger, C., Peters, A., Rouleau, G.A., Berger, K., Oexle, K., Di Angelantonio, E., Hinds, D.A., Müller-Myhsok, B., Winkelmann, J. in collaboration with the 23andMe Research Team and the DESIR study group. Identification of novel risk loci for restless legs syndrome in genome-wide association  studies in individuals of European ancestry: a meta-analysis. Lancet Neurol 2017; 16: 898–907. DOI: 10.1016/S1474-4422(17)30327-7.

Ferreira, R.C., Simons, H.Z., Thompson, W.S., Rainbow, D.B., Yang, X., Cutler, A.J., Oliveira, J., Castro Dopico, X., Smyth, D.J., Savinykh, N., Mashar, M., Vyse, T.J., Dunger, D.B., Baxendale, H., Chandra, A., Wallace, C., Todd, J.A., Wicker, L.S. and Pekalski, M.L. Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity. J.Autimm 2017, 84: 75-86. DOI: 10.1016/j.jaut.2017.07.009. 

Cutler, A.J., Oliveira, J., Ferreira, R.C., Challis, B., Walker, N.M., Caddy, S., Lu, J., Stevens, H.E., Smyth, D.J., Pekalski, M.L., Kennet, J., Hunter, K.M.D., Goodfellow, I., Wicker, L.S., Todd J.A. and Waldron-Lynch, F. (2017) Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial. Wellcome Open Research 2017, 2:28 DOI: 10.12688/wellcomeopenres.11300.3.

Burren, O.S., García, A.R., Javierre, B.M., Rainbow, D.B., Cairns, J., Cooper, N.J., Lambourne, J.J., Schofield, E., Dopico, X.C., Ferreira, R.C., Coulson, R., Burden, F., Rowlston, S.P., Downes, K., Wingett, S.W., Frontini, M., Ouwehand, W.H., Fraser, P., Spivakov, M., Todd, J.A., Wicker, L.S., Cutler, A.J., and Wallace, C. (2017) Chromosome contacts in activated T cells identify autoimmune disease candidate genes. Genome Biology (2017) 18:165 DOI 10.1186/s13059-017-1285-0

Pekalski, M.L, García, A.R., Ferreira, R.C., Rainbow, D.B., Smyth, D.J., Mashar, M., Brady, J., Savinykh,N., Dopico, X.C., Mahmood, S., Duley, S., Stevens, H.E., Walker, N.M., Cutler, A.J., Waldron-Lynch, F., Dunger, D.B., Shannon-Lowe, C., Coles, A.J., Jones, J.L., Wallace, C., Todd, J.A., and Wicker, L.S. (2017) Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2. JCI Insight. 2017;2(16):e93739. insight.93739

Fonseca, V.R., Agua-Doce, A., Maceiras, A.R., Pierson, W., Ribeiro, F., Romão, V.C., Pires, A.R., Lopes da Silva, S., Fonseca, J.E., Sousa, A.E., Linterman, M.A. and Graca, L. Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function. Science Immunology 2017, 2 issue 14. DOI: 10.1126/sciimmunol.aan1487.

Petersen, R., Lambourne, J.J., Javierre, B.M., Grassi, L., Kreuzhuber, R., Ruklisa, D., Rosa, I.M., Tomé, A.R., Elding, H., van Geffen, J.P., Jiang, T., Farrow, S., Cairns, J., Al-Subaie, A.M., Ashford, S., Attwood, A., Batista, J., Bouman, H., Burden, F., Choudry, F.A., Clarke, L., Flicek, P., Garner, S.F., Haimel, M., Kempster, C., Ladopoulos, V., Lenaerts, A-N., Materek, P.M., McKinney, H., Meacham, S., Mead, D., Nagy, M., Penkett, C.J., Rendon, A., Seyres, D., Sun, B., Tuna, S., van der Weide, M-E., Wingett, S.W., Martens, J.H., Stegle, O., Richardson, S., Vallier, L., Roberts, D.J., Freson, K., Wernisch, L., Stunnenberg, H.G., Danesh, J., Fraser, P., Soranzo, N., Butterworth, A.S., Heemskerk, J.W., Turro, E., Spivakov, M., Ouwehand, W.H., Astle, W.J., Downes, K., Kostadima, M. and Frontini, M. Platelet function is modified by common sequence variation in megakaryocyte super enhancers. Nature Communications 8:16058. DOI: 10.1038/ncomms16058.

Kelly, A.M., Garner, S.F., Foukaneli, T., Godec, T.R., Herbert, N., Kahan, B.C., Deary, A., Bakrania, L., Llewelyn, C., Ouwehand, W.H., Williamson, L.M., and Cardigan, R.A. (2017) The effect of variation in donor platelet function on transfusion outcome: a semirandomised controlled trial. Blood, 2017; DOI 10.1182/blood-2017-01-759258

Jackson, S.E., Sedikides, G.X., Okecha, G., Poole, E.L., Sinclair, J.H., and Wills, M.R. (2017) Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. Front. Immunol.2017. 8:733. doi: 10.3389/fimmu.2017.00733

Jackson, S.E., Redeker, A., Arens, R., van Baarle, D., van den Berg, S.P.H., Benedict, C.A., Čičin-Šain, L., Hill, A.B., and Wills, M.R. (2017) CMV immune evasion and manipulation of the immune system with aging. GeroScience June 2017. 39:273–291. DOI 10.1007/s11357-017-9986-6

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F.P., Culley, O.J., Danecek, P., Faulconbridge, A., Harrison, P.W., Kathuria, A., McCarthy, D., McCarthy, S.A., Meleckyte, R., Memari, Y., Moens, N., Soares, F., Mann, A., Streeter, I., Agu, C.A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S.R., Clarke, L., Halai, R., Kirton, C.M., Kolb-Kokocinski, A., Beales, P., Birney, E., Danovi, D., Lamond, A.I., Ouwehand, W.H., Vallier, L., Watt, F.M., Durbin, R., Stegle, O., Gaffney, D.J. (2017) Common genetic variation drives molecular heterogeneity in human iPSCs. Nature, June 2017, 546; 370-375. doi:10.1038/nature22403

Warrier, V., Grasby, K.L., Uzefovsky, F., Toro, R., Smith, P., Chakrabarti, B., Khadake, J., Mawbey-Adamson, E., Litterman, N., Hottenga, J.J., Lubke, G., Boomsma, D.I., Martin, N.G., Hatemi, P.K., Medland, S.E., Hinds, D.A., Bourgeron, T., and Baron-Cohen, S. (2017) Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition. Molecular Psychiatry advance online publication, 6 June 2017; doi:10.1038/mp.2017.122

Wynell-Mayow, W., Cash, D., Muniz-Tererra, G., Gkrania-Klotsas, E., and Khanduja, V. (2017) Factors Affecting Mortality and Length of Stay Following Clostridium Difficile Associated Diarrhoea: Validating A Consistent Scoring System. Archives of Clinical Microbiology June 2017. Vol.8 No.3:46. ISSN 1989-8436. DOI: 10.4172/1989-8436.100046

Ferreira, R.C., Rainbow, D.B., García, A.R., Pekalski, M.L., Porter, L., Oliveira, J.J., Waldron-Lynch, F., Wicker, L.S., Todd, J.A. (2017) In-depth immunophenotyping data of IL-6R on the human peripheral regulatory Tcell (Treg) compartment. Data in Brief 12 (2017) 676–691.

Ferreira, R.C., Rainbow, D.B., García, A.R., Pekalski, M.L., Porter, L., Oliveira, J.J., Waldron-Lynch, F., Wicker, L.S., and Todd, J.A. (2017) Human IL-6RhiTIGIT− CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile. Yclim (2017), doi: 10.1016/j.clim.2017.03.002

Passamonti, L., Luijten, M., Ziauddeen, H., Coyle-Gilchrist, I.T.S., Rittman, T., Brain, S.A.E., Regenthal, R., Franken, I.H.A., Sahakian, B.J., Bullmore, E.T., Robbins, T.W., and Ersche, K.D. (2017) Atomoxetine effects on attentional bias to drug-related cues in cocaine dependent individuals. Psychopharmacology May 2017. DOI 10.1007/s00213-017-4643-4

Naef, M., Müller, U., Linssen, A., Clark, L., Robbins, T.W., and Eisenegger, C. (2017) Effects of dopamine D2/D3 receptor antagonism on human planning and spatial working memory. Transl Psychiatry (2017) 7, e1107; doi:10.1038/tp.2017.56

Thomas, D.C., Clare, S., Sowerby, J.M., Pardo, M., Juss, J.K., Goulding, D.A., van der Weyden, L., Storisteanu, D., Prakash, A., Espéli, M., Flint, S., Lee, J.C., Hoenderdos, K., Kane, L., Harcourt, K., Mukhopadhyay, S., Umrania, Y., Antrobus, R.,Nathan, J.A., Adams, D.J., Bateman, A., Choudhary, J.S., Lyons, P.A., Condliffe, A.M., Chilvers, E.R., Dougan, G., and Smith, K.G.C. (2017) Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. J. Exp. Med. 2017 Vol. 214 No. 4 1111–1128

Jackson, S.E., Sedikides, G.X., Mason, G.M., Okecha, G., and Wills, M.R. (2017). Human Cytomegalovirus (HCMV)-Specific CD4_ T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro. Journal of Virology, March 2017 Volume 91 Issue 6 e02128-16,

Yang, P., Chorath, A., and Jiang, W. (2017) Identification and Validation Novel Risk Genes for Type 1 Diabetes – A Meta-Analysis. MED ONE Feb 2017,1:e170003. DOI: 10.20900/mo.20170003.

Ecker, S., Chen, L., Pancaldi. V., Bagger,F.O., Fernández, J.M., Carrillo de Santa Pau, E., Juan, D., Mann, A.L., Watt, S., Casale, F.P., Sidiropoulos, N., Rapin, N., Merkel, A., BLUEPRINT Consortium, Stunnenberg, H.G., Stegle, O., Frontini, M., Downes, K., Pastinen, T., Kuijpers, T.W., Rico, D., Valencia, A., Beck, S., Soranzo, N., and Paul, D.S. (2017) Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. Genome Biology. Jan 2017, 18:18. DOI 10.1186/s13059-017-1156-8


Farlik, M., Halbritter, F., Muller, F., Choudry, F.A., Ebert, P., Klughammer, J., Farrow, S., Santoro, A., Ciaurro, V., Mathur, A., Uppal, R., Stunnenberg, H.G., Ouwehand, W.H., Laurenti, E., Lengauer, T., Frontini, M., and Bock, C. (2016). DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation. 808 Cell Stem Cell 19, 808–822, December 1, 2016.

Schuyler, R.P., Merkel, A., Raineri, E., Altucci, L., Vellenga, E., Martens, J.H.A., Pourfarzad, F., Kuijpers, T.W., Burden, F., Farrow, S., Downes, K., Ouwehand, W.H., Clarke, L., Datta, A., Lowy, E., Flicek, P., Frontini, M., Stunnenberg, H.G., Martı´n-Subero, J.I., Gut, I., and Heath, S. (2016). Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems. Cell Reports 17, 2101–2111, November 15, 2016.

Breeze, C.E., Paul, D.S., van Dongen, J., Butcher, L.M., Ambrose, J.C., Barrett, J.E., Lowe, R., Rakyan, V.K., Iotchkova, V., Frontini, M., Downes, K., Ouwehand, W.H., Laperle, J., Jacques, P-E., Bourque, G., Bergmann, A.K., Siebert, R.,Vellenga, E., Saeed, S., Matarese, F., Martens, J.H.A., Stunnenberg, H.G., Teschendorff, A.E., Herrero, J., Birney, E., Dunham, I., and Beck, S. (2016). eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data. Cell Reports 17, 2137–2150, November 15, 2016.

Chen, L., Ge, B., Casale, F.P., Vasquez, L., Kwan, T., Garrido-Martı´n, D., Watt, S., Yan, Y., Kundu, K., Ecker, S., Datta, A., Richardson, D., Burden, F., Mead, D., Mann, A.L., Fernandez, J.M., Rowlston, S., Wilder, S.P., Farrow, S., Shao, X., John J. Lambourne, Adriana Redensek, Cornelis A. Albers, Vyacheslav Amstislavskiy, Sofie Ashford, Kim Berentsen, Lorenzo Bomba, Guillaume Bourque, David Bujold, Stephan Busche, Maxime Caron, Shu-Huang Chen, Warren Cheung, Oliver Delaneau, Emmanouil T. Dermitzakis, Heather Elding, Irina Colgiu, Frederik O. Bagger, Paul Flicek, Ehsan Habibi, Valentina Iotchkova, Eva Janssen-Megens, Bowon Kim, Hans Lehrach, Ernesto Lowy, Amit Mandoli, Filomena Matarese, Matthew T. Maurano, John A. Morris, Vera Pancaldi, Farzin Pourfarzad, Karola Rehnstrom, Augusto Rendon, Thomas Risch, Nilofar Sharifi, Marie-Michelle Simon, Marc Sultan, Alfonso Valencia, Klaudia Walter, Shuang-Yin Wang, Mattia Frontini, Stylianos E. Antonarakis, Laura Clarke, Marie-Laure Yaspo, Stephan Beck, Roderic Guigo, Daniel Rico, Joost H.A. Martens, Willem H. Ouwehand, Taco W. Kuijpers, Dirk S. Paul, Hendrik G. Stunnenberg, Oliver Stegle, Kate Downes, Tomi Pastinen, and Nicole Soranzo. (2016) Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell 167, 1398–1414, November 17, 2016.

Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G. Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck and R. David Leslie (2016) Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. NATURE COMMUNICATIONS | 7:13555 | DOI: 10.1038/ncomms13555

Biola M. Javierre, Oliver S. Burren, Steven P. Wilder, Roman Kreuzhuber, Steven M. Hill, Sven Sewitz, Jonathan Cairns, Steven W. Wingett, Csilla Va´ rnai, Michiel J. Thiecke, Frances Burden, Samantha Farrow, Antony J. Cutler, Karola Rehnstrom, Kate Downes, Luigi Grassi, Myrto Kostadima, Paula Freire-Pritchett, Fan Wang, The BLUEPRINT Consortium, Hendrik G. Stunnenberg, John A. Todd, Daniel R. Zerbino, Oliver Stegle, Willem H. Ouwehand, Mattia Frontini, Chris Wallace, Mikhail Spivakov, and Peter Fraser (2016) Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. Cell 167, 1369–1384, November 17, 2016.

William J. Astle, Heather Elding, Tao Jiang, Dave Allen, Dace Ruklisa, Alice L. Mann, Daniel Mead, Heleen Bouman, Fernando Riveros-Mckay, Myrto A. Kostadima, John J. Lambourne, Suthesh Sivapalaratnam, Kate Downes, Kousik Kundu, Lorenzo Bomba, Kim Berentsen, John R. Bradley, Louise C. Daugherty, Olivier Delaneau, Kathleen Freson, Stephen F. Garner, Luigi Grassi, Jose Guerrero, Matthias Haimel, Eva M. Janssen-Megens, Anita Kaan, Mihir Kamat, Bowon Kim, Amit Mandoli, Jonathan Marchini, Joost H.A. Martens, Stuart Meacham, Karyn Megy, Jared O’Connell, Romina Petersen, Nilofar Sharifi, Simon M. Sheard, James R. Staley, Salih Tuna, Martijn van der Ent, Klaudia Walter, Shuang-Yin Wang, Eleanor Wheeler, Steven P. Wilder, Valentina Iotchkova, Carmel Moore, Jennifer Sambrook, Hendrik G. Stunnenberg, Emanuele Di Angelantonio, Stephen Kaptoge, Taco W. Kuijpers, Enrique Carrillo-de-Santa-Pau, David Juan, Daniel Rico, Alfonso Valencia, Lu Chen, Bing Ge, Louella Vasquez, Tony Kwan, Diego Garrido-Martın, Stephen Watt, Ying Yang, Roderic Guigo, Stephan Beck, Dirk S. Paul, Tomi Pastinen, David Bujold, Guillaume Bourque, Mattia Frontini, John Danesh, David J. Roberts, Willem H. Ouwehand, Adam S. Butterworth, and Nicole Soranzo (2016) The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell 167, 1415–1429. November 17, 2016.

John A. Todd, Marina Evangelou, Antony J. Cutler, Marcin L. Pekalski, Neil M. Walker, Helen E. Stevens, Linsey Porter, Deborah J. Smyth, Daniel B. Rainbow, Ricardo C. Ferreira, Laura Esposito, Kara M. D. Hunter, Kevin Loudon, Kathryn Irons, Jennie H. Yang, Charles J. M. Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L. Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I. Tree, Mark Evans, Adrian P. Mander, Simon Bond,8, Linda S. Wicker and Frank Waldron-Lynch. (2016) Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2:A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. PLoS Med 13(10): e1002139. doi:10.1371/journal.pmed.1002139

Geoffrey S. Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M. Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S. Al-Lamki, Andrew J. Leishman, Steven J. Rust, Ross Stewart, Lutz Jermutus, John R. Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter and Robert W. Wilkinson (2016) Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy. Oncotarget, Advance Publications ,September 2016, 1-14. DOI: 10.18632/oncotarget.11943

Andréanne Morin, Tony Kwan, Bing Ge, Louis Letourneau, Maria Ban, Karolina Tandre, Maxime Caron, Johanna K. Sandling, Jonas Carlsson, Guillaume Bourque, Catherine Laprise, Alexandre Montpetit, Ann-Christine Syvanen, Lars Ronnblom, Stephen J. Sawcer, Mark G. Lathrop and Tomi Pastinen. (2016) Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells. BMC Medical Genomics (2016) 9:59 DOI 10.1186/s12920-016-0220-7

M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster, Gavin W Sewell, Svetlana Saveljeva, Jonathan W Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R Chilvers, Jules L Griffin Nicole C Kaneider, R Andres Floto, Mauro D’Amato, Allan Bradley, Michael J O Wakelam, Gordon Dougan & Arthur Kaser (2016)  C13orf31 (FAMIN) is a central regulator of immunometabolic function.  VOLUME 17 NUMBER 9 SEPTEMBER 2016. Nature immunology.  doi:10.1038/ni.3532

Roberts, L., Furnrohr, B.G., Vyse, T.J., and Rhodes, B. (2016) The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling. Clinical and Experimental Immunology, July 26, 2016. 185: 361–371. doi:10.1111/cei.12803

Davies, Jessica L., Thompson, Sara, Kaur-Sandhu, Harpreet, Sawcer, Stephen, Coles, Alasdair, Ban, Maria, Jones, Joanne. (2016) Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis. PLOS ONE. July 20, 2016.

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