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Publications

List of publications from CBR-supported research studies acknowledging the Cambridge BioResource

2018

Richard, A., Peters, J., Savinykh, N., Lee, J., Hawley, E., Meylan, F., Siegel, R., Lyons, P., Smith, K. Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease. PLOS Genetics 2018, volume 14, issue 9, Published on September 10, 2018. https://doi.org/10.1371/journal.pgen.1007458

Williams-Gray, C., Wijeyekoon, R., Scott, K., Hayat, S., Barker, R., Jones, J. Abnormalities of age-related T cell senescence in Parkinson's disease. Journal of Neuroinflammation 2018;15(1):166. https://doi.org/10.1186/s12974-018-1206-5

Wang, J., Ferreira, R., Lu, W., Farrow, S., Downes, K., Jermutus, L., Minter, R., R Al-Lamki,R., Pober, J., & Bradley, J. TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway. Nature, Scientific Reports, volume 8, Article number: 12079 (2018)

Smets, I., Fiddes, B., Garcia-Perez, J.E., He, D., Mallants, K., Liao, W., Dooley, J., Wang, G., Humblet-Baron, S., Dubois, B., Compston, A., Jones, J., Coles, A., Liston, A., Ban, M., Goris, A. and Sawcer, S. Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells. BRAIN 2018. DOI: 10.1093/brain/awx372.

Alasoo, K., Rodrigues, J., Mukhopadhyay, S., Knights, A., Mann, A., Kundu, K., HIPSCI Consortium, Hale, C., Dougan, G., and Gaffney, D. Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response. Nature Geneticsvolume 50, pages424–431 (2018)

2017

Schormair, B., Zhao, C., Bell, S., Tilch, E., Salminen, A.V., Pütz, B., Dauvilliers, Y., Stefani, A., Högl, B., Poewe, W., Kemlink, D., Sonka, K., Bachmann, C.G., Paulus, W., Trenkwalder, C., Oertel, W.H.o, Hornyak, M., Teder-Laving, M., Metspalu, A., Hadjigeorgiou, G.M., Polo, O., Fietze, I., Ross, O.A., Wszolek, Z., Butterworth, A.S., Soranzo, N., Ouwehand, W.H., Roberts, D.J., Danesh, J., Allen, R.P., Earley, C.J., Ondo, W.G., Xiong, L., Montplaisir, J., Gan-Or, Z., Perola, M., Vodicka, P., Dina, C., Franke, A., Tittmann, L., Stewart, A.F.R., Shah, S.H., Gieger, C., Peters, A., Rouleau, G.A., Berger, K., Oexle, K., Di Angelantonio, E., Hinds, D.A., Müller-Myhsok, B., Winkelmann, J. in collaboration with the 23andMe Research Team and the DESIR study group. Identification of novel risk loci for restless legs syndrome in genome-wide association  studies in individuals of European ancestry: a meta-analysis. Lancet Neurol 2017; 16: 898–907. DOI: 10.1016/S1474-4422(17)30327-7.

Ferreira, R.C., Simons, H.Z., Thompson, W.S., Rainbow, D.B., Yang, X., Cutler, A.J., Oliveira, J., Castro Dopico, X., Smyth, D.J., Savinykh, N., Mashar, M., Vyse, T.J., Dunger, D.B., Baxendale, H., Chandra, A., Wallace, C., Todd, J.A., Wicker, L.S. and Pekalski, M.L. Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity. J.Autimm 2017, 84: 75-86. DOI: 10.1016/j.jaut.2017.07.009. 

Cutler, A.J., Oliveira, J., Ferreira, R.C., Challis, B., Walker, N.M., Caddy, S., Lu, J., Stevens, H.E., Smyth, D.J., Pekalski, M.L., Kennet, J., Hunter, K.M.D., Goodfellow, I., Wicker, L.S., Todd J.A. and Waldron-Lynch, F. (2017) Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial. Wellcome Open Research 2017, 2:28 DOI: 10.12688/wellcomeopenres.11300.3.

Burren, O.S., García, A.R., Javierre, B.M., Rainbow, D.B., Cairns, J., Cooper, N.J., Lambourne, J.J., Schofield, E., Dopico, X.C., Ferreira, R.C., Coulson, R., Burden, F., Rowlston, S.P., Downes, K., Wingett, S.W., Frontini, M., Ouwehand, W.H., Fraser, P., Spivakov, M., Todd, J.A., Wicker, L.S., Cutler, A.J., and Wallace, C. (2017) Chromosome contacts in activated T cells identify autoimmune disease candidate genes. Genome Biology (2017) 18:165 DOI 10.1186/s13059-017-1285-0

Pekalski, M.L, García, A.R., Ferreira, R.C., Rainbow, D.B., Smyth, D.J., Mashar, M., Brady, J., Savinykh,N., Dopico, X.C., Mahmood, S., Duley, S., Stevens, H.E., Walker, N.M., Cutler, A.J., Waldron-Lynch, F., Dunger, D.B., Shannon-Lowe, C., Coles, A.J., Jones, J.L., Wallace, C., Todd, J.A., and Wicker, L.S. (2017) Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2. JCI Insight. 2017;2(16):e93739. https://doi.org/10.1172/jci. insight.93739

Fonseca, V.R., Agua-Doce, A., Maceiras, A.R., Pierson, W., Ribeiro, F., Romão, V.C., Pires, A.R., Lopes da Silva, S., Fonseca, J.E., Sousa, A.E., Linterman, M.A. and Graca, L. Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function. Science Immunology 2017, 2 issue 14. DOI: 10.1126/sciimmunol.aan1487.

Petersen, R., Lambourne, J.J., Javierre, B.M., Grassi, L., Kreuzhuber, R., Ruklisa, D., Rosa, I.M., Tomé, A.R., Elding, H., van Geffen, J.P., Jiang, T., Farrow, S., Cairns, J., Al-Subaie, A.M., Ashford, S., Attwood, A., Batista, J., Bouman, H., Burden, F., Choudry, F.A., Clarke, L., Flicek, P., Garner, S.F., Haimel, M., Kempster, C., Ladopoulos, V., Lenaerts, A-N., Materek, P.M., McKinney, H., Meacham, S., Mead, D., Nagy, M., Penkett, C.J., Rendon, A., Seyres, D., Sun, B., Tuna, S., van der Weide, M-E., Wingett, S.W., Martens, J.H., Stegle, O., Richardson, S., Vallier, L., Roberts, D.J., Freson, K., Wernisch, L., Stunnenberg, H.G., Danesh, J., Fraser, P., Soranzo, N., Butterworth, A.S., Heemskerk, J.W., Turro, E., Spivakov, M., Ouwehand, W.H., Astle, W.J., Downes, K., Kostadima, M. and Frontini, M. Platelet function is modified by common sequence variation in megakaryocyte super enhancers. Nature Communications 8:16058. DOI: 10.1038/ncomms16058.

Kelly, A.M., Garner, S.F., Foukaneli, T., Godec, T.R., Herbert, N., Kahan, B.C., Deary, A., Bakrania, L., Llewelyn, C., Ouwehand, W.H., Williamson, L.M., and Cardigan, R.A. (2017) The effect of variation in donor platelet function on transfusion outcome: a semirandomised controlled trial. Blood, 2017; DOI 10.1182/blood-2017-01-759258

Jackson, S.E., Sedikides, G.X., Okecha, G., Poole, E.L., Sinclair, J.H., and Wills, M.R. (2017) Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. Front. Immunol.2017. 8:733. doi: 10.3389/fimmu.2017.00733

Jackson, S.E., Redeker, A., Arens, R., van Baarle, D., van den Berg, S.P.H., Benedict, C.A., Čičin-Šain, L., Hill, A.B., and Wills, M.R. (2017) CMV immune evasion and manipulation of the immune system with aging. GeroScience June 2017. 39:273–291. DOI 10.1007/s11357-017-9986-6

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F.P., Culley, O.J., Danecek, P., Faulconbridge, A., Harrison, P.W., Kathuria, A., McCarthy, D., McCarthy, S.A., Meleckyte, R., Memari, Y., Moens, N., Soares, F., Mann, A., Streeter, I., Agu, C.A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S.R., Clarke, L., Halai, R., Kirton, C.M., Kolb-Kokocinski, A., Beales, P., Birney, E., Danovi, D., Lamond, A.I., Ouwehand, W.H., Vallier, L., Watt, F.M., Durbin, R., Stegle, O., Gaffney, D.J. (2017) Common genetic variation drives molecular heterogeneity in human iPSCs. Nature, June 2017, 546; 370-375. doi:10.1038/nature22403

Warrier, V., Grasby, K.L., Uzefovsky, F., Toro, R., Smith, P., Chakrabarti, B., Khadake, J., Mawbey-Adamson, E., Litterman, N., Hottenga, J.J., Lubke, G., Boomsma, D.I., Martin, N.G., Hatemi, P.K., Medland, S.E., Hinds, D.A., Bourgeron, T., and Baron-Cohen, S. (2017) Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition. Molecular Psychiatry advance online publication, 6 June 2017; doi:10.1038/mp.2017.122

Wynell-Mayow, W., Cash, D., Muniz-Tererra, G., Gkrania-Klotsas, E., and Khanduja, V. (2017) Factors Affecting Mortality and Length of Stay Following Clostridium Difficile Associated Diarrhoea: Validating A Consistent Scoring System. Archives of Clinical Microbiology June 2017. Vol.8 No.3:46. ISSN 1989-8436. DOI: 10.4172/1989-8436.100046

Ferreira, R.C., Rainbow, D.B., García, A.R., Pekalski, M.L., Porter, L., Oliveira, J.J., Waldron-Lynch, F., Wicker, L.S., Todd, J.A. (2017) In-depth immunophenotyping data of IL-6R on the human peripheral regulatory Tcell (Treg) compartment. Data in Brief 12 (2017) 676–691. http://dx.doi.org/10.1016/j.dib.2017.04.043

Ferreira, R.C., Rainbow, D.B., García, A.R., Pekalski, M.L., Porter, L., Oliveira, J.J., Waldron-Lynch, F., Wicker, L.S., and Todd, J.A. (2017) Human IL-6RhiTIGIT− CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile. Yclim (2017), doi: 10.1016/j.clim.2017.03.002

Passamonti, L., Luijten, M., Ziauddeen, H., Coyle-Gilchrist, I.T.S., Rittman, T., Brain, S.A.E., Regenthal, R., Franken, I.H.A., Sahakian, B.J., Bullmore, E.T., Robbins, T.W., and Ersche, K.D. (2017) Atomoxetine effects on attentional bias to drug-related cues in cocaine dependent individuals. Psychopharmacology May 2017. DOI 10.1007/s00213-017-4643-4

Naef, M., Müller, U., Linssen, A., Clark, L., Robbins, T.W., and Eisenegger, C. (2017) Effects of dopamine D2/D3 receptor antagonism on human planning and spatial working memory. Transl Psychiatry (2017) 7, e1107; doi:10.1038/tp.2017.56

Thomas, D.C., Clare, S., Sowerby, J.M., Pardo, M., Juss, J.K., Goulding, D.A., van der Weyden, L., Storisteanu, D., Prakash, A., Espéli, M., Flint, S., Lee, J.C., Hoenderdos, K., Kane, L., Harcourt, K., Mukhopadhyay, S., Umrania, Y., Antrobus, R.,Nathan, J.A., Adams, D.J., Bateman, A., Choudhary, J.S., Lyons, P.A., Condliffe, A.M., Chilvers, E.R., Dougan, G., and Smith, K.G.C. (2017) Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. J. Exp. Med. 2017 Vol. 214 No. 4 1111–1128 https://doi.org/10.1084/jem.20161382

Jackson, S.E., Sedikides, G.X., Mason, G.M., Okecha, G., and Wills, M.R. (2017). Human Cytomegalovirus (HCMV)-Specific CD4_ T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro. Journal of Virology, March 2017 Volume 91 Issue 6 e02128-16, doi.org/10.1128/JVI.02128-16.

Yang, P., Chorath, A., and Jiang, W. (2017) Identification and Validation Novel Risk Genes for Type 1 Diabetes – A Meta-Analysis. MED ONE Feb 2017,1:e170003. DOI: 10.20900/mo.20170003.

Ecker, S., Chen, L., Pancaldi. V., Bagger,F.O., Fernández, J.M., Carrillo de Santa Pau, E., Juan, D., Mann, A.L., Watt, S., Casale, F.P., Sidiropoulos, N., Rapin, N., Merkel, A., BLUEPRINT Consortium, Stunnenberg, H.G., Stegle, O., Frontini, M., Downes, K., Pastinen, T., Kuijpers, T.W., Rico, D., Valencia, A., Beck, S., Soranzo, N., and Paul, D.S. (2017) Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types. Genome Biology. Jan 2017, 18:18. DOI 10.1186/s13059-017-1156-8

2016

Farlik, M., Halbritter, F., Muller, F., Choudry, F.A., Ebert, P., Klughammer, J., Farrow, S., Santoro, A., Ciaurro, V., Mathur, A., Uppal, R., Stunnenberg, H.G., Ouwehand, W.H., Laurenti, E., Lengauer, T., Frontini, M., and Bock, C. (2016). DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation. 808 Cell Stem Cell 19, 808–822, December 1, 2016. http://dx.doi.org/10.1016/j.stem.2016.10.019

Schuyler, R.P., Merkel, A., Raineri, E., Altucci, L., Vellenga, E., Martens, J.H.A., Pourfarzad, F., Kuijpers, T.W., Burden, F., Farrow, S., Downes, K., Ouwehand, W.H., Clarke, L., Datta, A., Lowy, E., Flicek, P., Frontini, M., Stunnenberg, H.G., Martı´n-Subero, J.I., Gut, I., and Heath, S. (2016). Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems. Cell Reports 17, 2101–2111, November 15, 2016. http://dx.doi.org/10.1016/j.celrep.2016.10.054

Breeze, C.E., Paul, D.S., van Dongen, J., Butcher, L.M., Ambrose, J.C., Barrett, J.E., Lowe, R., Rakyan, V.K., Iotchkova, V., Frontini, M., Downes, K., Ouwehand, W.H., Laperle, J., Jacques, P-E., Bourque, G., Bergmann, A.K., Siebert, R.,Vellenga, E., Saeed, S., Matarese, F., Martens, J.H.A., Stunnenberg, H.G., Teschendorff, A.E., Herrero, J., Birney, E., Dunham, I., and Beck, S. (2016). eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data. Cell Reports 17, 2137–2150, November 15, 2016. http://dx.doi.org/10.1016/j.celrep.2016.10.059

Chen, L., Ge, B., Casale, F.P., Vasquez, L., Kwan, T., Garrido-Martı´n, D., Watt, S., Yan, Y., Kundu, K., Ecker, S., Datta, A., Richardson, D., Burden, F., Mead, D., Mann, A.L., Fernandez, J.M., Rowlston, S., Wilder, S.P., Farrow, S., Shao, X., John J. Lambourne, Adriana Redensek, Cornelis A. Albers, Vyacheslav Amstislavskiy, Sofie Ashford, Kim Berentsen, Lorenzo Bomba, Guillaume Bourque, David Bujold, Stephan Busche, Maxime Caron, Shu-Huang Chen, Warren Cheung, Oliver Delaneau, Emmanouil T. Dermitzakis, Heather Elding, Irina Colgiu, Frederik O. Bagger, Paul Flicek, Ehsan Habibi, Valentina Iotchkova, Eva Janssen-Megens, Bowon Kim, Hans Lehrach, Ernesto Lowy, Amit Mandoli, Filomena Matarese, Matthew T. Maurano, John A. Morris, Vera Pancaldi, Farzin Pourfarzad, Karola Rehnstrom, Augusto Rendon, Thomas Risch, Nilofar Sharifi, Marie-Michelle Simon, Marc Sultan, Alfonso Valencia, Klaudia Walter, Shuang-Yin Wang, Mattia Frontini, Stylianos E. Antonarakis, Laura Clarke, Marie-Laure Yaspo, Stephan Beck, Roderic Guigo, Daniel Rico, Joost H.A. Martens, Willem H. Ouwehand, Taco W. Kuijpers, Dirk S. Paul, Hendrik G. Stunnenberg, Oliver Stegle, Kate Downes, Tomi Pastinen, and Nicole Soranzo. (2016) Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell 167, 1398–1414, November 17, 2016. http://dx.doi.org/10.1016/j.cell.2016.10.026

Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G. Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck and R. David Leslie (2016) Increased DNA methylation variability in type 1 diabetes across three immune effector cell types. NATURE COMMUNICATIONS | 7:13555 | DOI: 10.1038/ncomms13555

Biola M. Javierre, Oliver S. Burren, Steven P. Wilder, Roman Kreuzhuber, Steven M. Hill, Sven Sewitz, Jonathan Cairns, Steven W. Wingett, Csilla Va´ rnai, Michiel J. Thiecke, Frances Burden, Samantha Farrow, Antony J. Cutler, Karola Rehnstrom, Kate Downes, Luigi Grassi, Myrto Kostadima, Paula Freire-Pritchett, Fan Wang, The BLUEPRINT Consortium, Hendrik G. Stunnenberg, John A. Todd, Daniel R. Zerbino, Oliver Stegle, Willem H. Ouwehand, Mattia Frontini, Chris Wallace, Mikhail Spivakov, and Peter Fraser (2016) Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. Cell 167, 1369–1384, November 17, 2016. http://dx.doi.org/10.1016/j.cell.2016.09.037

William J. Astle, Heather Elding, Tao Jiang, Dave Allen, Dace Ruklisa, Alice L. Mann, Daniel Mead, Heleen Bouman, Fernando Riveros-Mckay, Myrto A. Kostadima, John J. Lambourne, Suthesh Sivapalaratnam, Kate Downes, Kousik Kundu, Lorenzo Bomba, Kim Berentsen, John R. Bradley, Louise C. Daugherty, Olivier Delaneau, Kathleen Freson, Stephen F. Garner, Luigi Grassi, Jose Guerrero, Matthias Haimel, Eva M. Janssen-Megens, Anita Kaan, Mihir Kamat, Bowon Kim, Amit Mandoli, Jonathan Marchini, Joost H.A. Martens, Stuart Meacham, Karyn Megy, Jared O’Connell, Romina Petersen, Nilofar Sharifi, Simon M. Sheard, James R. Staley, Salih Tuna, Martijn van der Ent, Klaudia Walter, Shuang-Yin Wang, Eleanor Wheeler, Steven P. Wilder, Valentina Iotchkova, Carmel Moore, Jennifer Sambrook, Hendrik G. Stunnenberg, Emanuele Di Angelantonio, Stephen Kaptoge, Taco W. Kuijpers, Enrique Carrillo-de-Santa-Pau, David Juan, Daniel Rico, Alfonso Valencia, Lu Chen, Bing Ge, Louella Vasquez, Tony Kwan, Diego Garrido-Martın, Stephen Watt, Ying Yang, Roderic Guigo, Stephan Beck, Dirk S. Paul, Tomi Pastinen, David Bujold, Guillaume Bourque, Mattia Frontini, John Danesh, David J. Roberts, Willem H. Ouwehand, Adam S. Butterworth, and Nicole Soranzo (2016) The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell 167, 1415–1429. November 17, 2016. http://dx.doi.org/10.1016/j.cell.2016.10.042

John A. Todd, Marina Evangelou, Antony J. Cutler, Marcin L. Pekalski, Neil M. Walker, Helen E. Stevens, Linsey Porter, Deborah J. Smyth, Daniel B. Rainbow, Ricardo C. Ferreira, Laura Esposito, Kara M. D. Hunter, Kevin Loudon, Kathryn Irons, Jennie H. Yang, Charles J. M. Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L. Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I. Tree, Mark Evans, Adrian P. Mander, Simon Bond,8, Linda S. Wicker and Frank Waldron-Lynch. (2016) Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2:A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. PLoS Med 13(10): e1002139. doi:10.1371/journal.pmed.1002139

Geoffrey S. Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M. Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S. Al-Lamki, Andrew J. Leishman, Steven J. Rust, Ross Stewart, Lutz Jermutus, John R. Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter and Robert W. Wilkinson (2016) Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy. Oncotarget, Advance Publications ,September 2016, 1-14. DOI: 10.18632/oncotarget.11943

Andréanne Morin, Tony Kwan, Bing Ge, Louis Letourneau, Maria Ban, Karolina Tandre, Maxime Caron, Johanna K. Sandling, Jonas Carlsson, Guillaume Bourque, Catherine Laprise, Alexandre Montpetit, Ann-Christine Syvanen, Lars Ronnblom, Stephen J. Sawcer, Mark G. Lathrop and Tomi Pastinen. (2016) Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells. BMC Medical Genomics (2016) 9:59 DOI 10.1186/s12920-016-0220-7

M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster, Gavin W Sewell, Svetlana Saveljeva, Jonathan W Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R Chilvers, Jules L Griffin Nicole C Kaneider, R Andres Floto, Mauro D’Amato, Allan Bradley, Michael J O Wakelam, Gordon Dougan & Arthur Kaser (2016)  C13orf31 (FAMIN) is a central regulator of immunometabolic function.  VOLUME 17 NUMBER 9 SEPTEMBER 2016. Nature immunology.  doi:10.1038/ni.3532

Roberts, L., Furnrohr, B.G., Vyse, T.J., and Rhodes, B. (2016) The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling. Clinical and Experimental Immunology, July 26, 2016. 185: 361–371. doi:10.1111/cei.12803

Davies, Jessica L., Thompson, Sara, Kaur-Sandhu, Harpreet, Sawcer, Stephen, Coles, Alasdair, Ban, Maria, Jones, Joanne. (2016) Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis. PLOS ONE. July 20, 2016. http://dx.doi.org/10.1371/journal.pone.0158327

Libertini, E., Heath, S.C., Hamoudi, R.A., Gut, M., Ziller, M.J., Czyz, A., Ruotti, V., Stunnenberg, H.G., Frontini, M., Ouwehand, W.H., Meissner, A., Gut, I.G., and Beck, S. (2016) Information recovery from low coverage whole-genome bisulfite sequencing. Nature Communications | 7:11306 | DOI: 10.1038/ncomms11306

Ersche, K.D., Gillan, C.M., Jones, S., Williams, G.B., Ward, L.H.E., Luijten, M., de Wit, S., Sahakian, B.J., Bullmore, E.T., and Robbins, T.W. (2016) Carrots and sticks fail to change behavior in cocaine addiction. 17 June 2016 • VOL 352 ISSUE 6292. Science sciencemag.org. http://dx.doi.org/10.17863/CAM.122

Fernandez-Egea, E., Vértes, P.E., Flint, S.M., Turner, L., Mustafa, S., Hatton, A., Smith, K.G.C., Lyons, P.A., and Bullmore, E.T. (2016). Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia. PLoS ONE 11 (5): e0155631. doi:10.1371/journal.pone.0155631

Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds, Pradeep J Nathan, Sam R Miller, Bhopinder K Sarai, Kay Maltby, Disala Fernando, Liling Warren, Louise K Hosking, Dawn Waterworth, Anna Korzeniowska, Beta Win, Duncan B Richards, Lakshmi Vasist Johnson, Paul C Fletcher and Edward T Bullmore. (2016) Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype. Neuropsychopharmacology (2016) 41, 2647–2657; doi:10.1038/npp.2016.60

Carr EJ, Dooley J, Garcia-Perez JE, Lagou V, Lee JC, Wouters C, Meyts I, Goris A, Boeckxstaens G, Linterman MA, Liston A. (2016) The cellular composition of the human immune system is shaped by ageing and cohabitation. Nat Immunol. 2016 Apr;17(4):461-8. doi: 10.1038/ni.3371. Epub 2016 Feb 15.

Sleigh, Alison, Lupson, Victoria, Thankamony, Ajay, Dunger, David B., Savage, David B., Carpenter, T. Adrian, Kemp, Graha, J. (2016) Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using 31P magnetic resonance spectroscopy. Scientific Reports, 2016 Jan 11;6:19057. doi: 10.1038/srep19057; published online 11 January 2016

Lachmann P. J., Lay E., Seilly D. J., Buchberger A., Schwaeble W., Khadake J. (2016) Further studies of the down-regulation by Factor I of the C3b feedback cycle using endotoxin as a soluble activator and red cells as a source of CR1 on sera of different complotype. The Journal of Translational Immunology, Jan 2016, 183(1), 150-156, doi: 10.1111/cei.12714; published online 5 November 2015

2015

Bell, C.J., Sun, Y., Nowak, U.M., Clark, J., Howlett, S., Pekalski, M.L., Yang, X., Ast, O., Waldhauer, I., Freimoser-Grundschober, A., Moessner, E., Umana, P., Klein, C., Hosse, R.J., Wicker, L.S,, Peterson, L.B. (2015). Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. J Autoimmun. Jan; 56:66-80. doi: 10.1016/j.jaut.2014.10.002. Epub 2014 Oct 30.

Dopico, X.C., Evangelou, M., Ferreira, R.C., Guo, H., Pekalski, M.L., Smyth, D.J., Cooper, N., Burren, O.S., Fulford, A.J., Hennig, BJ.., Prentice, A.M., Ziegler, A.G., Bonifacio, E., Wallace, C., Todd, J.A. (2015). Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat Commun. May 12;6:7000. doi: 10.1038/ncomms8000.

Heywood, J., Evangelou, M., Goymer, D., Kennet, J., Anselmiova, K., Guy, C., O'Brien, C., Nutland, S., Brown, J., Walker, N.M., Todd, J.A., Waldron-Lynch, F. (2015). Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D). Trials. Mar 11; 16(1):86. doi: 10.1186/s13063-015-0583-7.

Liley, J., Wallace, C. (2015). A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics. PLoS Genet. Feb 6; 11(2):e1004926. doi: 10.1371/journal.pgen.1004926. eCollection 2015.

2014

Clatworthy, M.R., Harford, S.K., Mathews, R.J., Smith, K.G. (2014). FcgRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis. Proc Natl Acad Sci USA, 111(50), 17971-17976. doi:10.1073/pnas.1413915111

Downes, K., Marcovecchio, M. L., Clarke, P., Cooper, J. D., Ferreira, R. C., Howson, J. M. M., Jolley, J., Nutland, S., Stevens, H.E., Walker, N.M., Wallace, C., Dunger, D.B., Todd, J. A. (2014). Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients. Diabetologia, 57(2), 366-372. doi:10.1007/s00125-013-3113-8

Eisenegger, C., Naef, M., Linssen, A., Clark, L., Gandamaneni, P.K., Muller, U., Robbins, T.W. (2014). Role of Dopamine D2 Receptors in Human Reinforcement Learning. Neuropsychopharmacology, 39, 2366-2375. doi:10.1038/npp.2014.84; published online 7 May 2014

Esposito, L., Hunter, K. M. D., Clark, J., Rainbow, D. B., Stevens, H., Denesha, J., Duley, S., Dawson, S., Coleman, G., Nutland, S., Bell, G.L., Moran, C., Pekalski, M., Todd, J.A., Wicker, L. S. (2014). Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles. The Journal of Immunology Author Choice, 193(2), 889-900. doi:10.4049/jimmunol.1303389.

Evangelou, M., Smyth, D. J., Fortune, M. D., Burren, O. S., Walker, N. M., Guo, H., Onengut-Gumuscu, S., Chen,W.M., Concannon, P., Rich, S.S., Todd, J.A., Wallace, C. (2014). A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations. Genetic Epidemiology, 38(8), 661-670. doi:10.1002/gepi.21853.

Ferreira, R. C., Guo, H., Coulson, R. M. R., Smyth, D. J., Pekalski, M. L., Burren, O. S., Cutler, A.J., Doecke, J.D., Flint, S., McKinney, E.F., Lyons, P.A., Smith, K.G.C., Achenbach, P., Beyerlein, A., Dunger, B.B., Clayton, D.G., Wicker, L.S., Todd, J.A., Bonifacio, E., Wallace, C., Ziegler, A.-G. (2014). A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes. Diabetes, 63(7), 2538-2550. doi:10.2337/db13-1777.

Kennedy, N.A., Walker, A.W., Berry, S.H., Lamb, C.A., Lewis, S., Mansfield, J., Parkes, M., Parkhill, J., Probert, C., Read, D., Satsangi, J., Simpkins, R., Tomlinson, D., Tremelling, M., Nutland, S., Hold, G.L., Lees, C.W., UK IBD Genetics Consortium. (2014). The Impact of NOD2 variants on gut microbiota in Crohn's Disease and healthy controls. Gut, 63:A159-A160 doi:10.1136/gutjnl-2014-307263.342.

Lay, E., Nutland, S., Smith, J.E., Hiles, I., Smith, R.A.G., Seilly, D.J., Buchberger, A., Schwaeble, W., Lachmann, P.J. (2014) Complotype affects the extent of down-regulation by Factor I of the C3b feedback cycle in-vitro. Clin Exp Immunol. 2014. doi:10.1111/cei.12437

Thompson, W. S., Pekalski, M. L., Simons, H. Z., Smyth, D. J., Castro-Dopico, X., Guo, H., Guy, C., Dunger, D.B., Arif, S., Peakman, M., Wallace, C., Wicker, L.S., Todd, J.A., Ferreira, R. C. (2014). Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes. Clinical and Experimental Immunology, 177(3), 571-585. doi:10.1111/cei.12362

2013

Di Meglio, P., Villanova, F., Napolitano, L., Tosi, I., Terranova Barberio, M., Mak, R.K., Nutland, S., Smith, C.H., Barker, J.N.W.N., Todd, J.A., Nestle, F. O. (2013). The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients. The Journal of Investigative Dermatology, 133(10), 2381-2389. doi:10.1038/jid.2013.170

Ferreira, R. C., Freitag, D. F., Cutler, A. J., Howson, J. M. M., Rainbow, D. B., Smyth, D. J., Kaptoge, S., Clarke, P., Boreham, C., Coulson, R.M., Pekalski, M.L., Chen, W.M., Onengut-Gumuscu, S., Rich, S.S., Butterworth, A.S., Malarstig, A., Danesh, J., Todd, J. A. (2013). Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases. PLoS Genetics, 9(4), e1003444. doi:10.1371/journal.pgen.1003444

Gregersen, P.K., Manjarrez-Orduno, N. (2013) FOXO in the Hole: Leveraging GWAS for Outcome and Function. Cell, 155(1) 11-12. doi:10.1016/j.cell.2013.08.050

Hunt, K.A., Mistry, V., Bockett, N.A., Ahmed, T., Ban, M., Barker, J.N., Barrett, J.C., Blackburn, H., Brand, O., Capon, F., Compston, A., Gough, S.C.L., Jostins, L., Kong, Y., Lee, J.C., Lek, M., MacArthur, D.G., Mansfield, J.C., Mathew, C.G., Mein, C.A., Mirza, M., Nutland, S., onengut-Gumuscu, S., Papouli, E., Parkes, M., Rich, S.C., Sawcer, S., Satsangi, J., Simmonds, M.J., Trembath, R.C., Walker, N.M., Wozniak, E., Todd, J.A., Simpson, M.A., Plagnol, V. & van Heel, D.A. (2013) Negligible impact on missing heritability of autoimmune-locus rare coding-region variants. Nature, 498(7453):232-235. doi:10.1038/nature12170.

Lee, J.c., Espeli, M., Anderson, C.A., Linterman, M.A., Pocock, J.M., Williams, N.J., Roberts, R., Viatte, S., Fu, B., Peshu, N., Hien, T.T., Phu, N.H., Wesley, E., Edwards, C., Ahmad, T., Mansfield, J.C., Gearry, R., Dunstan, S., Willisams, T.N., Barton, A., Vinuesa, C.G., UK IBD Genetics Consortium, Parkes, M., Lyons, P.A., Smith, K.G.C. (2013). Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway. Cell, 155(1), 57-69. doi:10.1016/j.cell.2013.08.034

Pekalski, M.L., Ferreira, R.C., Coulson, R.M.R., Cutler, A.J., Guo, H., Smyth, D., Downes, K., Dendrou, C.A., Castro-Dopico, X., Esposito, L., Coleman, G., Stevens, H., Nutland, S., Walker, N.M., Guy, C., Dunger, D.B., Wallace, C., Tree, T.I.M., Todd, J.A. & Wicker, L.S. (2013) Post-thymic expansion in human CD4 naive T cells defined by expression of functional high affinity IL-2 receptors. J Immunol. 190 (6), 2554-2566. doi:10.4049/jimmunol.1202914.

2012

Albers, C.A., Paul, D.S., Schulze, H., Freson, K., Stephens, J.C., Smethurst, P.A., Jolley, J.J., Cvejic, A., Kostadima, M., Bertone, P., Breuning, M.H., Debili, N., Deloukas, P., Favier, R., Fiedler J., Hobbs, C.M., Huang, N., Hurles, M.E., Kiddle, G., Krapels, I., Nurden, P., Ruivenkamp, C.A.L., Sambrook, J.G., Smith, K., Stemple, D.L., Strauss, G., Thys, C., van Geet, C., Newbury-Ecob*, R., Ouwehand*, W.H. & Ghevaert*, C. (2012) Inheritance of low-frequency regulatory SNPs and a rare null mutation in exon-junction complex subunit RBM8A causes TAR. Nature Genetics Nat Genet. 2012 February 26; 44(4): 435-S2. doi:10.1038/ng.1083.

Garg, G., Tyler, J.R., Yang, J.H.M., Cutler, A.J., Downes, K., Pekalski, M., Bell, G.L., Nutland, S., Peakman, M., Todd, J.A., Wicker, L.S. & Tree, T.I.M. (2012) Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+ CD25+ regulatory T cell function. J Immunol. Prepublished online 28 March 2012; doi:10.4049/jimmunol.1100272.

Wallace, C., Rotival, M., Cooper, J.D., Rice, C.M., Yang, J.H.M., McNeill, M., Smyth, D.J., Niblett, D., Cambien, F., The Cardiogenics Consortium, Tiret, L., Todd, J.A., Clayton, D.G. & Blankenberg, S. (2012) Statistical colocalisation of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet. advanced online publication 10.1093/hmg/dds098.

2011

Hunt, K.A., Smyth, D.J., Balschun, T., Ban, M., Mistry, V., Ahmad, T., Anand, V., Barrett, J.C., Bhaw-Rosun, L., Bockett, N.A., Brand, O.J., Brouwer, E., Concannon, P., Cooper, J.D., Dias, K.M., van Diemen, C.C., Dubois, P.C., Edkins, S., F�lster-Holst, R., Fransen, K., Glass, D.N., Heap, G.A.R., Hofmann, S., Huizinga, T.W.J., Hunt, S., Langford, C., Lee, J., Mansfield, J., Marrosu, M.G., Mathew, C.G., Mein, C.A., M�ller-Quernheim, J., Nutland, S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N.J., Posthumus, M.D., Potter, S., Rosati, G., Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M.J., Sudman, M., Thompson, S.D., Toes, R., Trynka, G., Vyse, T.J., Walker, N.M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Type 1 Diabetes Genetics Consortium, UK Inflammatory Bowel Disease (IBD) Genetics Consortium , Wellcome Trust Case Control Consortium , Weersma, R.K., Gough, S.C.L., Sawcer, S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S.S., Todd, J.A. & van Heel, D.A. (2011) Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet. Published online: 27 December 2011, doi:10.1038/ng.1037

Lo, B., Swafford, A.D., Shafer-Weaver, K.A., Jerome, L.F., Rakhlin, L., Mathern, D.R., Callahan, C.A., Jiang, P., Davison, L.J., Stevens, H.E., Lucas, C.L., White, J., von Borstel, R., Todd, J.A. & Lenardo, M.J. (2011) Antibodies against insulin measured by electrochemiluminiscence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status. J Transl Med. 9 (1), 203.

Swafford, A., Howson, J., Davison, L.J., Wallace, C., Smyth, D.J., Schuilenburg, H., Maisuria-Armer, M., Mistry, T., Lenardo, M.J. & Todd, J.A. (2011) An allele of IKZF1 (IKAROS) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes, 60 (3), 1041-1044.

Yang, J.H., Downes, K., Howson, J.M., Nutland, S., Stevens, H.E., Walker, N.M. & Todd, J.A. (2011) Evidence of association with type 1 diabetes in the SLC11A1 gene region. BMC Medical Genetics. Published online: 27 April 2011, doi:10.1186/1471-2350-12-59

2010

Dhami, P., Saffrey, P., Bruce, A.W., Dillon, S.C., Chiang, K., Bonhoure, N., Koch, C.M., Bye, J., James, K., Foad, N.S., Ellis, P., Watkins, N.A., Ouwehand, W.H., Langford, C., Andrews, R.M., Dunham, I. & Vetrie, D. (2010) Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS ONE. 5, e12339.

Downes, K., Pekalski, M., Angus, K.L., Hardy, M., Nutland, S., Smyth, D.J., Walker, N.M., Wallace, C. & Todd, J.A. (2010) Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes. PLoS ONE. 5(9): e12646. doi:10.1371/journal.pone.0012646

Goodall, A.H., Burns, P., Salles, I., Macaulay, I.C., Jones, C.I., Ardissino, D., de Bono, B., Bray, S.L., Deckmyn, H., Dudbridge, F., Fitzgerald, D.J., Garner, S.F., Gusnanto, A., Koch, K., Langford, C., O'Connor, M.N., Rice, C.M., Stemple, D., Stephens, J., Trip, M.D., Zwaginga, J.J., Samani, N.J., Watkins, N.A., Maguire, P.B. & Ouwehand, W.H. (2010) Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood. 116, 4646-4656.

Heap, G.A., Yang, J.H.M., Downes, K., Healy, B.C., Hunt, K.A., Bockett, N., Franke, L., Dubois, P.C., Mein, C.A., Dobson, R.J., Albert, T.J., Rodesch, M.J., Clayton, D.G., Todd, J.A., van Heel, D.A. & Plagnol, V. (2010) Genome-wide analysis of allelic expression imbalance in human primary cells by high throughput transcriptome resequencing. Hum. Mol. Genet. (2010) 19 (1): 122-134. doi:10.1093/hmg/ddp473

Von dem Hagen, E.A.H., Passamonti, L., Nutland, S., Sambrook, J. & Calder, A.J. (2010) The serotonin transporter gene polymorphism and the effect of baseline on amygdala response to emotional faces. Neuropsychologia (2011). doi:10.1016/j.neuropsychologia.2010.12.013

2009

Dendrou, C.A., Fung, E., Esposito, L., Todd, J.A., Wicker, L.S. & Plagnol, V. (2009) Fluorescence Intensity Normalisation: Correcting for Time Effects in Large-Scale Flow Cytometric Analysis. Advances in Bioinformatics. vol. 2009, Article ID 476106, doi:10.1155/2009/476106.

Dendrou, C.A., Plagnol, V., Fung, E., Yang, J.H., Downes, K., Cooper, J.D., Nutland, S., Coleman, G., Himsworth, M., Hardy, M., Burren, O., Healy, B., Walker, N.M., Koch, K., Ouwehand, W.H., Bradley, J.R., Wareham, N.J., Todd, J.A. & Wicker, L.S. (2009) Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nature Genetics. 41, 1011-1015.

Gregersen, P.K. (2009) Closing the gap between genotype and phenotype. Nature Genetics. 41, 958 - 959, doi:10.1038/ng0909-958

Holbrook, L., Watkins, N.A., Simmonds, A.D., Jones, C.I., Ouwehand, W.H. & Gibbins, J.M. (2009) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. British Journal of Haematology. Vol 148, Issue 4: 8

Jones, C.I., Bray, S., Garner, S.F., Stephens, J., de Bono, B., Angenent, W.G., Bentley, D., Burns, P., Coffey, A., Deloukas, P., Earthrowl, M., Farndale, R.W., Hoylaerts, M.F., Koch, K., Rankin, A., Rice, C.M., Rogers, J., Samani, N.J., Steward, M., Walker, A., Watkins, N.A., Akkerman, J.W., Dudbridge, F., Goodall, A.H. & Ouwehand, W.H. (2009) A functional genomics approach reveals novel quantitative trait loci associated with platelet signalling pathways. Blood. 2009 Aug 13;114(7):1286-7.

Meisinger, C., Prokisch, H., Gieger, C., Soranzo, N., Mehta, D., Rosskopf, D., Lichtner, P., Klopp, N., Stephens, J., Watkins, N.A., Deloukas, P., Greinacher, A., Koenig, W., Nauck, M., Rimmbach, C., Volzke, H., Peters, A., Illig, T., Ouwehand, W.H., Meitinger, T., Wichmann, H.E. & Doring, A. (2009) A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet. 84, 66-71.

Soranzo, N., Rendon, A., Gieger, C., Jones, C.I., Watkins, N.A., Menzel, S., Doring, A., Stephens, J., Prokisch, H., Erber, W., Potter, S.C., Bray, S.L., Burns, P., Jolley, J., Falchi, M., Kuhnel, B., Erdmann, J., Schunkert, H., Samani, N.J., Illig, T., Garner, S.F., Rankin, A., Meisinger, C., Bradley, J.R., Thein, S.L., Goodall, A.H., Spector, T.D., Deloukas, P. & Ouwehand, W.H. (2009) A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood. 113, 3831-3837.

Soranzo, N., Rivadeneira, F., Chinappen-Horsley, U., Malkina, I., Richards, J.B., Hammond, N., Stolk, L., Nica, A., Inouye, M., Hofman, A., Stephens, J., Wheeler, E., Arp, P., Gwilliam, R., Jhamai, P.M., Potter, S., Chaney, A., Ghori, M.J.R., Ravindrarajah, R., Ermakov, S., Estrada, K., Pols, H.A.P., Williams, F.M., McArdle, W.L., van Meurs, J.B., Loos, R.J.F., Dermitzakis, E.T., Ahmadi, K.R., Hart, D.J., Ouwehand, W.H., Wareham, N.J., Barroso, I., Sandhu, M.S., Strachan, D.P., Livshits, G., Spector, T.D., Uitterlinden, A.G. & Deloukas, P. (2009) Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size. PLoS Genet. 5(4): e1000445. doi:10.1371/journal.pgen.1000445

Soranzo, N., Spector, T.D., Mangino, M., Kuhnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B., Chen, L., Li, M., Salo, P., Voight, B.F., Burns, P., Laskowski, R.A., Xue, Y., Menzel, S., Altshuler, D., Bradley, J.R., Bumpstead, S., Burnett, M.S., Devaney, J., Doring, A., Elosua, R., Epstein, S.E., Erber, W., Falchi, M., Garner, S.F., Ghori, M.J., Goodall, A.H, Gwilliam, R., Hakonarson, H.H., Hall, A.S., Hammond, N., Hengstenberg, C., Illig, T., Konig, I.R., Knouff, C.W., McPherson, R., Melander, O., Mooser, V., Nauck, M., Nieminen, M.S., O'Donnell, C.J., Peltonen, L., Potter, S.C., Prokisch, H., Rader, D.J., Rice, C.M., Roberts, R., Salomaa, V., Sambrook, J., Schreiber, S., Schunkert, H., Schwartz, S.M., Serbanovic-Canic, J., Sinisalo, J., Siscovick, D.S., Stark, K., Surakka, I., Stephens, J., Thompson, J.R., Volker, U., Volzke, H., Watkins, N.A., Wells, G.A., Wichmann, H.E., Van Heel, D.A., Tyler-Smith, C., Thein, S.L., Kathiresan, S., Perola, M., Reilly, M.P., Stewart, A.F., Erdmann, J., Samani, N.J., Meisinger, C., Greinacher, A., Deloukas, P., Ouwehand, W.H. & Gieger, C. (2009) A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. Published online: 11 October 2009, doi:10.1038/ng.467

Watkins, N.A., Gusnanto, A., de Bono, B., De, S., Miranda-Saavedra, D., Hardie, D.L., Angenent, W.G., Attwood, A.P., Ellis, P.D., Erber, W., Foad, N.S., Garner, S.F., Isacke, C.M., Jolley, J., Koch, K., Macaulay, I.C., Morley, S.L., Rendon, A., Rice, K.M., Taylor, N., Thijssen-Timmer, D.C., Tijssen, M.R., van der Schoot, C.E., Wernisch, L., Winzer, T., Dudbridge, F., Buckley, C.D., Langford, C.F., Teichmann, S., Gottgens, B. & Ouwehand, W.H. (2009) A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood. 113, e1-9.

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